Fastest Way to Get Anathema of the Primes in Diablo 4 Lord of Hatred | Boss Drops & Horadric Cube Full Guide!

In Diablo 4 Lord of Hatred expansion, Warlocks gained a brand new unique weapon, Anathema of the Primes, a two-handed sword.

As a completely new weapon, Anathema of the Primes has its own unique effects and introduces many interesting new build options for Warlocks. For players who enjoy using Warlocks, it can significantly improve their damage output and combat experience.

What are the uses of Anathema of the Primes?

Archfiend Demonform is the main reason for this weapon’s high strength, and combined with its unique effects, many interesting builds can be discovered.

Unique effects of Anathema of the Primes

It has very prominent unique effects. First, when you hit an enemy with a Core Skill, it increases the damage you deal to them, up to 20%. This is the prerequisite for its powerful output.

Second, it can convert all your Archfiend Demonform Skill Variants into Core Skills, which can synergize with its other effect mentioned earlier, creating a very powerful synergy.

Furthermore, at this point, your skills will no longer consume Dominance; you will use Wrath to maintain skill casting.

Warlock Builds Around Anathema of the Primes

You can choose to use the default Core Skills to maximize its effectiveness, which will also improve damage output. However, for Warlock players, the weapon’s unique effects offer many new build options.

These builds are meticulously designed, with each component creating a very logical synergy. They clearly leverage the weapon’s strengths more effectively than the default Core Skills. Here are some widely accepted builds:

Demonic Smash Rampage Build

The core of this build lies in Anathema of the Primes and Lurid Pact.

Lurid Pact, a unique Warlock ring, not only significantly increases the damage of your Rampage, but also gains even greater damage and area-of-effect damage as you defeat more enemies in combat, and this effect stacks continuously.

With the combined effect of these two unique items, your Warlock will become a devastating damage dealer like Leap Barbarian, weaving through enemy lines and growing stronger with each attack.

This build is incredibly easy to master, requiring no complex skill combinations. Simply keep enemies falling without thinking to significantly and consistently boost Rampage’s damage output, making enemy elimination increasingly easy.

Sin Demon Build

The core of this build, besides Anathema of the Primes, lies in Hecaton Chasm, another unique ring for Warlock.

Its function is to increase your Tyrant’s Grasp damage by up to 120% and summon five additional demonic hands.

Furthermore, you can choose Nails of the Gore-Crowned to further enhance your potential. This item strengthens your Hellion Sting, allowing it to automatically damage enemies alongside your attacks while you are in Demonform.

While this build offers the satisfying feeling of constantly maintaining Demonform and enjoys positive community reviews, it has a smaller user base compared to Demonic Smash Rampage build.

In short, both builds centered around Anathema of the Primes have their own distinct advantages and maintain a high level of strength.

How to obtain Anathema of the Primes?

You can obtain this equipment in Diablo 4 through several methods, especially with the help of Horadric Cube from Lord of Hatred, making it relatively easy to acquire.

Farming Andariel

This is the most basic method. Andariel is currently the only boss that can drop this unique item. You need to go to Hanged Man’s Hall and possess Greater Lair Key.

Therefore, you need to continuously kill lesser lair bosses. It’s important to know that Torment level determines the drop rate of Greater Lair Key. When you are at lower Torment levels, you may need to spend some time accumulating enough keys to repeatedly challenge Andariel.

Horadric Cube

If, unfortunately, Andariel doesn’t deliver what you want, or you’re tired of repeatedly farming Andariel, you can choose Horadric Cube, which is actually the most recommended method.

After unlocking Horadric Cube, you can find it in Skovos and easily use it to obtain Diablo 4 items best suited for your character. This method is highly reliable; you don’t need to rely on those unpredictable and disheartening drop rates.

The recipe for Anathema of the Primes obtained from Horadric Cube includes:

• 1 Common Two-Handed Sword
• 1 Enhanced Primordial Dust
• 1 Raw Primordial Dust

The advantage of this method is that obtaining these materials in the game is significantly easier than repeatedly farming Greater Lair Keys. It can definitely save you a lot of valuable time during your Diablo 4 gameplay.

Drop from Enemies and Chests

You can still obtain any items by killing enemies and opening chests, but this is extremely random, so players shouldn’t have high expectations for this method.

Purveyor of Curiosity

This method is also not recommended. You might hope to consume Murmuring Obols to randomly give you some decent equipment, bringing you some surprises. However, its chance of getting Diablo 4 Anathema of the Primes from among the many weapons in Diablo 4 is extremely slim.

Considering all four methods, Horadric Cube is definitely the best way to easily obtain any equipment you want in Diablo 4. Don’t waste this mechanism that has returned in Lord of Hatred.

Overall, Anathema of the Primes has a good unique effect and a matching Warlock build, making it a worthwhile piece of equipment to acquire. Horadric Cube is definitely your first choice for obtaining it, so go try it!